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Researchers are still discovering the various metabolic effect of coffee, but what is well known that it has numerous effects. Most metabolic effects of coffee occur due to its content of different alkaloids, and caffeine is most prominent among them.
Few people know that the effects of a cup of coffee can last for almost a day. Just consider the fact that half-life of caffeine could be up to 10 hours.
Coffee is most commonly consumed or loved due to its effect on the central nervous system. It has a stimulatory effect on the brain; it increases wakefulness and attention. Higher doses of caffeine may affect the working of almost every organ. Very high doses may cause tachycardia, increased respiration rate, and even seizures.
Coffee inhibits the so-called adenosine receptors, which is thought to be mostly responsible for its impact on the central nervous system. It is also known to affect the release of various neurotransmitters in the brain like dopamine, serotonin, glutamate, GABA, and so on.
Coffee also inhibits phosphodiesterase enzymes, thus increasing the concentration of cAMP. Higher cAMP promotes muscle contraction, exercise tolerance, lipolysis, fat metabolism. This same action is also responsible for its cardio stimulatory activity. It also relaxes bronchial muscles, thus may help breathe better, especially if someone is living with asthma or COPD.
Another mode through with coffee may improve muscle function is through its effect on calcium channels; it enhances calcium intake by a sarcoplasmic reticulum of skeletal muscles, thus increasing contraction.
Apart from the increased heart rate, it increases coronary blood flow. It also affects the working of lungs, generally increasing aerobic capacity or exercise tolerance.
Coffee also boosts blood flow to kidneys and thus increases diuresis, which increases its potential of interaction with various medications, though only mildly.
Interestingly, recent research shows that coffee may inhibit endocannabinoid system, a network of receptors stimulated by cannabis. It means that it may alter the effect of cannabis on the brain.
The final effect of coffee and steroids will be difficult to predict. In most cases,the interaction will be mild and will not have much importance. Coffee will boost the metabolism of steroids; it will increase diuresis and removal of steroids from the body. However, in practice, these effects will be mild, until or unless one is addicted to coffee and drinks more than 7-8 cups a day.
Recent studies have shown that eight cups of coffee a day may interact with steroids, facilitating their secretion, which happens not only due to increased diuresis but also because of the complex interaction of coffee with various steroid pathways.
In short, a few cups of coffee a day may not change the working of steroids. It may improve exercise tolerance to some extent, and thus may have beneficial effects. However, drinking eight or more cups of coffee may negatively interact with steroids, reducing their efficacy.